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Jacksonville Jaguars vs. Arizona Cardinals Start Em Sit Em Week 12 2025 Fantasy Football Guide

Jeff Snow
cardinals quarterback qb fantasy football awards

The Jacksonville Jaguars have emerged as this year’s surprise story, reshaping the AFC landscape. Meanwhile, the Cardinals are struggling and may be forced into a pass-heavy script, creating fantasy opportunities across multiple positions. Week 12 could see both QBs and skill players post significant numbers.

START ’EM

Sep 14, 2025; Cincinnati, Ohio, USA; Jacksonville Jaguars running back Bhayshul Tuten (33) runs the ball during the first quarter against the Cincinnati Bengals at Paycor Stadium. Mandatory Credit: Joseph Maiorana-Imagn Images

Trevor Lawrence — QB, Jaguars

Lawrence has found the end zone in recent weeks and continues to produce efficiently. Expect 230+ yards and at least 1 TD. Reliable QB1 option in all formats.

Jacoby Brissett — QB, Cardinals

Brissett’s 400-yard explosion last week proves he thrives in high-volume passing games. Expect another strong outing if the Cardinals fall behind early. QB1/FLEX for deeper leagues.

Travis Etienne — RB, Jaguars

ETN splits carries with Bhayshul Tuten but is still the main back. Higher touchdown volume and usage make him a confident start. RB1 upside.

Trey McBride — TE, Cardinals

McBride has been efficient and a primary red-zone target. TE1/2 potential depending on league depth.

Why Bhayshul Tuten Might Just Be Getting Started for Jaguars – Andy Guach via SI.com

Bhayshul Tuten — RB, Jaguars

True split role, but Tuten has shown the ability to produce. Could steal a score in limited touches. FLEX-worthy.

Jakobi Meyers — WR, Jaguars FLEX

Meyers’ emergence has been perfectly timed. Expect 5–6 catches for ~70 yards. High-volume FLEX option.

Michael Wilson — WR, Cardinals

Wilson had a solid outing last week when Arizona was forced to pass. Another high-target game is likely if the game script continues.

Bam Knight — RB, Cardinals

Demercado is out, giving Knight a clear path to work. Should see goal-line touches and short-yardage usage.

Greg Dortch And 3 More Fantasy Football Wide Receiver Streamers For Week 12 – Ryan Shea via SI.com

Greg Dortch — WR, Cardinals (Sleeper)

Deep-league sleeper. If the Cardinals fall behind and Brissett airs it out, Dortch could see multiple targets and a score. Worth the bench in 12+ team leagues.

FINAL TAKEAWAY

This game is likely to be high-scoring and QB-friendly, especially if the Cardinals fall behind early.

• Jaguars: Lawrence and Etienne anchor the fantasy upside.

• Cardinals: Brissett, McBride, and emerging WRs like Meyers/Wilson provide PPR and touchdown upside.

• Deep leagues: Dortch is the perfect sleeper if Arizona is forced to air it out.

Expect a shootout with multiple fantasy-friendly options on both sides.