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NFL

Denver Broncos (1-1) at Los Angeles Chargers (2-0) Preview, Prediction & Odds | Week 3, 2025 

A classic AFC West rivalry is set to unfold as the Denver Broncos travel to SoFi Stadium to take on the undefeated Los Angeles Chargers.  

los angeles chargers
Aug 16, 2025; Inglewood, California, USA; Los Angeles Chargers quarterback Justin Herbert (10) talks with wide receiver Keenan Allen (13) against the Los Angeles Rams in the first half at SoFi Stadium. Mandatory Credit: Kirby Lee-Imagn Images
Denver Broncos (1-1) at Los Angeles Chargers (2-0)
Game Details: Sunday, September 21, 4 p.m EST
Location: SoFi Stadium, Inglewood, CA
Where to Watch: CBS

A classic AFC West rivalry is set to unfold as the Denver Broncos travel to SoFi Stadium to take on the undefeated Los Angeles Chargers.  

For Los Angeles, the start to the 2025 season couldn’t have gone better. With two divisional wins already under their belt against the Kansas City Chiefs and Las Vegas Raiders, they are riding a wave of momentum. For Denver, it’s a different story. After a less-than-convincing Week 1 win, the team is reeling from a last-second defeat to the Indianapolis Colts, a game filled with costly mistakes that they can’t afford to repeat against a very dangerous Chargers squad.

Betting Odds

Team Spread Money Line Total
Denver Broncos+2.5+130Over 45.5
Los Angeles Chargers-2.5-154Under 45.5

** Odds Subject to Change – Courtesy of FanDuel**

Tale of The Tape

Denver BroncosTeam Stats – Avg Per GameLos Angeles Chargers
24Points Per Game23.5
186Passing Yards Per Game270
134.5Rushing Yards Per Game85.5
20.5Opponents Points Per Game Allowed15
184Opponents Pass Yards Allowed 199.5
119Opponents Rush Yards Allowed 83

Key Details

Denver Broncos

The Denver Broncos are in a race to improve, and fast. After a tough loss to the Colts, the focus is on eliminating the critical errors that plagued them in Week 2, including penalties, turnovers, and missed assignments. Quarterback Bo Nix has already turned the ball over four times this season, a trend that cannot continue against the Chargers’ opportunistic defense.

Despite the recent struggles, there are bright spots. Second-year receiver Troy Franklin had a breakout performance against the Colts, setting career highs with eight receptions for 89 yards and a touchdown. The connection between Nix and Franklin, which dates back to their college days at Oregon, could be a key factor if the Broncos hope to keep pace. The defense, while allowing over 450 yards to Indianapolis, was stout in the red zone, giving the offense a chance to win late. Now, they face the challenge of containing a red-hot Herbert and proving they can bounce back from adversity.

Los Angeles Chargers

The Chargers are 2-0, and while quarterback Justin Herbert has been stellar, it’s the defense that has been the talk of the town. Under Defensive Coordinator Jesse Minter, the unit has been suffocating, leading the charge in their Monday night victory over the Raiders. They held Las Vegas to just nine points and 218 total yards, intercepting quarterback Geno Smith three times.

The defense swarmed the Raiders, with seven different players recording multiple passes defensed. This defensive prowess has allowed the Chargers to start the season with a perfect 2-0 record against the spread and has them looking like legitimate contenders in the AFC. With Herbert playing mistake-free football, throwing for 560 yards and five touchdowns without a single interception through two games, Los Angeles has a balanced attack that can win in multiple ways. They are clicking on all cylinders and look to continue their divisional dominance at home.

Prediction

There is a lot of the season to go, but here is the way too early Super Bowl Prediction: Green Bay Packers vs. Los Angeles Chargers. This statement makes it obvious who will win this game, and many more this season.

Final Pick

Los Angeles Chargers  -2.5

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