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Top MLB DFS Start‘em/Sit‘em Lineups For July 22nd

Jordan Ramos
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July is ending in nine days, and fantasy players could continue the week with today’s top MLB DFS lineups and fantasy stacks. Wednesday’s full slate of games will continue the new week with style. With the week heating up and July ending soon, fantasy players could win cash prizes with today’s top MLB DFS lineups and fantasy stacks.

Wednesday’s slate of 15 games will continue the week in style with the New York Mets ending their series against the Milwaukee Brewers. Another game where fantasy players could win cash prizes is the New York Yankees having a doubleheader with the Pittsburgh Pirates.

With the new week on a hot start, fantasy players could win cash prizes with today’s top MLB DFS lineups and fantasy stacks.

July 22nd Top MLB DFS Lineup Starters 

1B Paul Goldschmidt, Pittsburgh Pirates at New York Yankees ($3,800 – DraftKings/$3,000-FanDuel)

To start Wednesday’s slate of games, Paul Goldschmidt should be in your top MLB DFS lineups against the Pirates. In the win against the Pirates, Goldschmidt went 1-for-4 with a strikeout. 

Goldschmidt has been having a strong season and could deliver another strong performance. Fantasy players could see multi-hit games from Goldschmidt in the doubleheader. 

3B Isaac Paredes, Miami Marlins at Houston Astros ($3,900 – DraftKings/2,900-Fanduel)

Isaac Paredes of the Houston Astros should be in today’s top MLB DFS lineups to start the week against the Marlins. In the win against the Marlins, Paredes went 2-for-4 with a three-run home run. 

Paredes has been having a strong season and could deliver another great game tonight. Fantasy players could see a multi-RBI game from the Astros veteran infielder. 

OF Ian Happ, Detroit Tigers at Chicago Cubs ($4,000 – DraftKings/3,200-Fanduel)

The last player to add to your fantasy lineups is Ian Happ of the Chicago Cubs to continue the new week. In the blowout win against the Tigers, Happ went 1-for-3 with an RBI and a walk. 

Happ has been having a strong season with a .758 OPS and could deliver another strong performance. Fantasy players could see a multi-RBI game from Happ tonight. 

July 22nd Top MLB DFS Lineup Benchwarmers 

OF Byron Buxton, Minnesota Twins at Cleveland Guardians ($5,900 – DraftKings/$3,500-FanDuel)

For today’s top MLB DFS benchwarmers, Byron Buxton is the first player fantasy players should add to their benches for Wednesday night’s games. In the loss to the Guardians, Buxton went 1-for-4. 

Buxton has been having a strong season but could struggle against the Guardians tonight. Fantasy players could see a multi-strikeout performance from the Twins veteran star. 

SS Otto Lopez, Miami Marlins at Houston Astros ($4,600 – DraftKings/3,600-Fanduel)

Otto Lopez of the Miami Marlins is another player who should be on your fantasy bench to continue the week. In the loss to the Astros, Lopez went 0-for-3 with two walks and a strikeout. 

Lopez is having a great season but could struggle against the Astros again. Fantasy players could see a multi-strikeout game from Lopez. 

OF Kyle Schwarber, Los Angeles Dodgers at Philadelphia Phillies ($6,000 – DraftKings/$4,100-Fanduel) 

Kyle Schwarber, of the Philadelphia Phillies, should be the last player on your top MLB DFS bench for Wednesday’s game against the Dodgers. In the loss to the Dodgers, Schwarber went 0-for-4 with two strikeouts. 

Schwarber has been struggling with being hitless in his past three games. Fantasy players could see another multi-strikeout game from Schwarber tonight. 

 Total Apex Media Stack Of The Day

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Jul 29, 2025; San Diego, California, USA; San Diego Padres first baseman Luis Arraez (4) celebrates with center fielder Jackson Merrill (3) after defeating the New York Mets at Petco Park. Mandatory Credit: David Frerker-Imagn Images

Wednesday’s top MLB DFS stack for today’s slate should be the San Diego Padres’  Fernando Tatis Jr, Jackson Merrill, and Ty France. The Padres are having an inconsistent season, but could have a strong game against the Braves. With the trade deadline a week away, fantasy players could take advantage of this week’s top MLB DFS lineup stack with the Padres. 

The first player for today’s top MLB DFS lineup stack should be Tatis, who could have a great game against the Braves. In the win against the Braves, Tatis went 3-for-5 with a two-run home run, three RBIs, and a strikeout. Tatis is having a frustrating season with poor power numbers but a solid .752 OPS. Fantasy players could see a multi-hit game from the Padres star outfielder. 

Another player for today’s fantasy stack should be Merrill, who has been sluggish this season but could have a great game today. In the win against the Braves, Merrill went 2-for-4 with a home run and a walk. Merrill has been having a sluggish season, but could have another solid game against the Braves today. Fantasy players could see a multi-hit game from the Padres’ young outfielder. 

The last player for today’s top MLB DFS lineup stack should be France, who is having a great season for the Padres. In the win against the Braves, France went 2-for-5 with an RBI and three strikeouts. France has been having a strong season with an .890 OPS and 41 RBIs. Fantasy players could see a multi-hit game from the Padres veteran slugger. With the season on fire, fantasy players could win cash prizes with today’s top MLB DFS lineups and fantasy stacks.

Jordan Ramos is a journalism graduate writing for sports, betting, fantasy and other interests. Jordan has knowledge of New York sports for the last 15 years, with baseball, football, and basketball being his main topics, along with gaming, news writing, and media studies.