NFL

Kyle Juszczyk injury: 49ers fullback out

San Francisco 49ers fullback Kyle Juszczyk hyperextended his knee in Sunday's win over Denver and could miss multiple weeks, according to ESPN's Adam Schefter.

george kittle
Jun 11, 2025; Santa Clara, CA, USA; San Francisco 49ers tight end George Kittle (85) jokes with fullback Kyle Juszczyk (44) during a team OTA at Levi's Stadium. Mandatory Credit: D. Ross Cameron-Imagn Images

San Francisco 49ers fullback Kyle Juszczyk hyperextended his knee in Sunday’s win over Denver and could miss multiple weeks, according to ESPN’s Adam Schefter. Initial tests showed hyperextension; Juszczyk underwent an MRI Monday to determine the full extent of the injury.

Kyle Juszczyk: What The Source Said

Schefter reported the fullback could miss multiple weeks. The 49ers have not announced an injured reserve designation or official status.

Who Replaces Him In The Backfield

San Francisco has not announced a replacement fullback. In Juszczyk’s absence, the 49ers may rely on second-string options or adjust their packages to accommodate available personnel.

Season Context

Juszczyk is a key blocker in the 49ers’ run-heavy offense. Through Week 4, he anchored short-yardage and goal-line packages, critical to San Francisco’s ground-attack system. His absence forces the team to adapt blocking assignments in their power running plays.

What’s Next

The 49ers play the Seattle Seahawks on Sunday, Oct. 12 in Week 5. Another update on Juszczyk’s status is expected after the MRI results are reviewed.

Reporting from NFL.com contributed to this story.

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