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Indianapolis Colts vs. Kansas City Chiefs Start Em Sit Em WEEK 12 2025 Fantasy Football

Jeff Snow
chiefs

The Chiefs are stumbling, and pressure is rising as they fight to avoid a late-season collapse. Meanwhile, the Colts are coming off a bye, rested, confident, and hunting a statement win that would push them to a stunning 9–2. This matchup has major fantasy playoff implications and plenty of fantasy volatility on both sides.

Below are your Week 12 ratings + breakdown.

START ’EM

Colts
Oct 26, 2025; Indianapolis, Indiana, USA; Indianapolis Colts running back Jonathan Taylor (28) celebrates after the game against the Tennessee Titans at Lucas Oil Stadium. Mandatory Credit: Robert Goddin-Imagn Images

Daniel Jones — QB, Colts

Start Rating: (4/5)

Projection contingent on him playing

Monitor his calf injury, but if active, Jones should clear 230 yards and a TD, with real rushing upside against a Chiefs defense that has cracked in recent weeks.

Jonathan Taylor — RB, Colts

Start Rating: (5/5)

KC has struggled against physical run games all year. Taylor is fresh off a bye and should feast between the tackles with scoring upside.

Michael Pittman Jr — WR, Colts

Start Rating: (4/5)

WR1 volume + favorable slot perimeter matchups. Should find plenty of work similar to what Denver WRs did vs KC.

Alec Pierce — WR, Colts

Start Rating: (3/5)

Strong Flex / Deep-league starter. Production rising weekly, downfield shots + red zone usage growing.

Tyler Warren — TE, Colts

Start Rating: (4/5)

Quietl,y one of the best values at TE this season. He can absolutely repeat what Kincaid did to Kansas City.

Sleeper – Josh Downs — WR, Colts

Start Rating: (2.5/5)

Red-zone chemistry + third-option reliability. Great plug-and-play in bye/injury trouble.

Josh Downs and the art of moving the chains – Andrew Ariz via Stampede Blue

Kansas City Chiefs

Patrick Mahomes — QB

Start Rating: (4.5/5)

Backs against the wall. Expect volume + multiple scores in desperation mode.

Travis Kelce — TE

Start Rating: (5/5)

It’s crunch time, and Mahomes trusts nobody more. Red zone TD feels very possible.

Kareem Hunt — RB

Start Rating: (3/5)

More consistent than Pacheco with him out, so Hunt is more active in the passing game in those games. Strong FLEX.

‘It’s a One-Game Season’ – Chiefs vs. Colts Preview w/ Kareem Hunt | Defending the Kingdom via chiefs.com

Rashee Rice — WR

Start Rating: (2.5/5)

Tough matchup. Low-end flex only.

Xavier Worthy — WR (Deep Leagues)

Start Rating: (2/5)

Deep multi-flex consideration. May roam free while Rice is shadowed.

🚫 SIT ’EM

Hollywood Brown — WR, Chiefs

Sit Confidence: High

This matchup does not favor splash-dependent receivers. Bench with confidence.

Chiefs D/ST (Conditional)

Sit if Daniel Jones plays

Start only if he’s ruled OUT

They’ve been unreliable & exposed vs efficient offenses.

FINAL TAKEAWAY

This matchup is a crossroads game:

Colts = momentum, health, fresh legs

Chiefs = desperation, pressure, uncertainty

Expect:

• Taylor dominating the clock

• Mahomes forced into volume mode

• Pittman + Kelce anchoring passing attacks

• Pierce & Hunt turning into pivotal FLEX plays

If Jones suits up, the Colts control this game.

If not, this becomes chaos.

Either way…this one will shape fantasy playoff fates.