Cardinals Face Uphill Battle with Marvin Harrison Jr. Ruled Out with Concussion
Arizona Cardinals wide receiver Marvin Harrison Jr. will not return to Sunday’s game against the Indianapolis Colts after suffering a concussion in the second quarter, dealing a significant blow to the team’s offensive plans.
Cardinals now have downgraded WR Marvin Harrison Jr. to out due to a concussion. https://t.co/SLUI74Qow7
— Adam Schefter (@AdamSchefter) October 12, 2025
The Injury Occurrence
Harrison was injured during what should have been a routine 21-yard reception at Lucas Oil Stadium. The promising rookie’s head made contact with the turf at the end of the catch, immediately raising concerns on the sideline. After being evaluated in the medical tent, Harrison was escorted to the locker room by trainers for further concussion evaluation.
The Cardinals officially ruled Harrison out for the remainder of the contest, confirming the severity of the head injury that cut short what was expected to be an emotional homecoming for the young receiver.
Impact on Cardinals Offense
Harrison’s absence creates immediate challenges for Arizona’s passing attack. Before his departure, he had managed two catches for 32 yards, including the play that resulted in his injury. His loss removes one of quarterback Kyler Murray’s most reliable targets and forces the Cardinals to adjust their offensive game plan on the fly.
The timing couldn’t be worse for Arizona, which entered the game trailing the Colts 14-7 at the two-minute warning when Harrison’s status was officially announced.
Personal Significance of the Game
This matchup held special meaning for Harrison, whose father, Marvin Harrison Sr., enjoyed a Hall of Fame career playing on the same Lucas Oil Stadium field for the Colts. The younger Harrison had expressed excitement about his first opportunity to play in Indianapolis, making Sunday’s injury all the more disappointing.
The emotional weight of playing where his father made his mark in NFL history added another layer to what was already a crucial divisional matchup for the Cardinals.
Looking Ahead
Harrison’s injury raises immediate concerns about the Cardinals’ depth at wide receiver and their ability to maintain offensive consistency without their top target at receiver. The team will need other receivers to step up in his absence, while Harrison enters the NFL’s concussion protocol.
The Cardinals coaching staff now faces the challenge of redesigning their offensive approach without one of their most promising young weapons, particularly as they attempt to mount a comeback against Indianapolis.
